Home » Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics by Bryan L Roth
Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics Bryan L Roth

Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics

Bryan L Roth

Published January 10th 2010
ISBN : 9781280832130
ebook
642 pages
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 About the Book 

A comprehensive, state-of-the-art review of our current understanding of the molecular and structural biology of 5-HT receptors and their potential use for drug discovery. The authors describe the anatomical, cellular, and subcellular distribution ofMoreA comprehensive, state-of-the-art review of our current understanding of the molecular and structural biology of 5-HT receptors and their potential use for drug discovery. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction.